Long COVID in children: A closer look reveals lasting impacts

A comprehensive review in Pediatrics highlights the significant impact of post-acute sequelae of SARS-CoV-2 (PASC) in children, revealing a wide range of long-term symptoms and the need for further research on its prevalence, risk factors, and mechanisms.


In a recent study published in the journal Pediatrics , a large team of scientists from the United States (U.S.) reviewed existing studies on post-acute sequelae of coronavirus disease 2019 (COVID-19) (PASC) to understand the long-term impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in the pediatric population, including factors such as prevalence, clinical characteristics, risk factors, and underlying mechanisms.

STATE-OF-THE-ART REVIEW - Postacute Sequelae of SARS-CoV-2 in Children . Image Credit: Donkeyworx / Shutterstock The global impact of the COVID-19 pandemic has touched multiple spheres of life, with economic and social consequences apart from the massive effect on the medical and healthcare fields. Studies have shown that the pandemic has disproportionately affected specific racial and socioeconomic groups.

Furthermore, a significant portion of the population continues to struggle with persistent and debilitating aftereffects and symptoms of COVID-19, which has now been called PASC or long coronavirus disease (long COVID). Estimates indicate that the U.S.

had approximately 20% pediatric cases of COVID-19, of which 10%–20% were thought to develop into PASC, which translates to roughly 5.8 million children in the country. The present study summarizes the current understanding of the epidemiology, prevalence, underlying mechanisms, clinical characteristics, and outcomes of PASC in the pediatric population.

The review found no consens.