Leading virologists from over 40 countries are raising concerns over the escalating threat posed by H5N1 avian flu, a virus that can cause severe symptoms in humans, including coughing, body aches, fatigue, and pneumonia. In a commentary published this week in The Lancet Regional Health–Americas , scientists from the Global Virus Network (GVN) are urging global leaders to take urgent action, drawing on lessons learned from the COVID-19 pandemic. The experts highlight that sporadic human infections in the United States, with no known contact with infected animals, suggest the possibility of viral adaptation for efficient human-to-human transmission.
“In the U.S., sporadic human infections with no known contact with infected animals highlight the possibility of viral adaptation for efficient human-to-human transmission,” GVN scientists state in their commentary.
At the same time, the virus continues to circulate among wild birds, backyard flocks, and migratory species, further increasing the risk to both humans and domestic animals. “The virus’s persistence in wildlife populations, combined with its potential for mutation, significantly amplifies the global threat,” the experts warned. The virologists are calling on world leaders to bolster surveillance systems, improve biosecurity protocols, and prepare for the potential of human-to-human viral transmission.
“Understanding the current landscape of H5N1 infections is critical for effective prevention and response,” said Dr. Sten H. Vermund, Chief Medical Officer of the GVN and Dean of the USF Health College of Public Health at the University of South Florida.
He added in a press release, “The virus’s ability to infect both animals and humans, combined with recent genetic changes, underscores the importance of proactive surveillance and rapid response measures.” The commentary also underscores the severe consequences of the virus on both animal populations and humans. More than 995 dairy cow herds and at least 70 individuals have contracted H5N1, including severe cases and the first reported death from the virus in the United States.
Since 2022, the virus has spread across all 50 U.S. states and Canada, leading to the loss or culling of more than 168 million poultry animals.
Despite the lack of documented human-to-human transmission, experts warn that the virus could mutate or combine with other flu viruses, making it more transmissible. To mitigate the growing threat of H5N1, the researchers have made several key recommendations for global leaders and public health authorities: Also Read: Can Eating Too Much Chicken Increase Your Cancer Risk? Here Is New Study.
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Could H5N1 Avian Flu Spark The Next Pandemic? Top Virologists Warn Of Growing Threat

Leading virologists from over 40 countries are sounding the alarm over the growing threat of H5N1 avian flu, urging global leaders to act swiftly to prevent a potential pandemic. As the virus continues to spread among animals and humans, experts warn that mutations could enable it to evolve into a more transmissible strain.